280559-53-7Relevant academic research and scientific papers
Synthesis of a new class of cathepsin B inhibitors exploiting a unique reaction cascade
Nagao, Yoshimitsu,Sano, Shigeki,Morimoto, Kenji,Kakegawa, Hisao,Takatani, Tadanobu,Shiro, Motoo,Katunuma, Nobuhiko
, p. 2419 - 2424 (2000)
Chiral 5-substituted 3-pyrrolin-2-ones bearing L-Ile-L-Pro-OH or L-Phe- NHCH2Ph were successfully synthesized by utilizing a characteristic reaction cascade based on alkaline hydrolysis of the corresponding diethyl α-hydroxy- α-(β-propiolamide)malonates. Among the synthesized chiral pyrrolinones, compound 5S-9 proved to be the most potent inhibitor against cathepsin B. (C) 2000 Elsevier Science Ltd.
