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1-(4-BROMOBENZYL)-4-METHYLPERHYDRO-1,4-DIAZEPINE is a perhydrodiazepine derivative with the molecular formula C13H17BrN. It is a chemical compound that contains a bromine atom and a methyl group attached to a diazepine ring. 1-(4-BROMOBENZYL)-4-METHYLPERHYDRO-1,4-DIAZEPINE has potential applications in medicinal chemistry and pharmaceutical research, and it may exhibit neurological or psychoactive effects when tested in experimental studies. Its precise properties and uses are still being investigated, and further research is needed to fully understand its potential applications and effects.

280560-78-3

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280560-78-3 Usage

Uses

Used in Pharmaceutical Research:
1-(4-BROMOBENZYL)-4-METHYLPERHYDRO-1,4-DIAZEPINE is used as a research compound for exploring its potential neurological or psychoactive effects in experimental studies. Its unique chemical structure and properties make it a promising candidate for the development of new therapeutic agents.
Used in Medicinal Chemistry:
1-(4-BROMOBENZYL)-4-METHYLPERHYDRO-1,4-DIAZEPINE is used as a building block or intermediate in the synthesis of more complex molecules with potential therapeutic applications. Its chemical properties and reactivity can be exploited to create novel compounds with improved pharmacological profiles.
Note: Since the provided materials do not specify any particular industry or application type, the uses listed above are general and based on the potential of the compound in the fields of pharmaceutical research and medicinal chemistry. Further research and development may lead to more specific applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 280560-78-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,5,6 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 280560-78:
(8*2)+(7*8)+(6*0)+(5*5)+(4*6)+(3*0)+(2*7)+(1*8)=143
143 % 10 = 3
So 280560-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H19BrN2/c1-15-7-2-8-16(10-9-15)11-12-3-5-13(14)6-4-12/h3-6H,2,7-11H2,1H3

280560-78-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(4-bromophenyl)methyl]-4-methyl-1,4-diazepane

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:280560-78-3 SDS

280560-78-3Downstream Products

280560-78-3Relevant academic research and scientific papers

Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development

Bachovchin, Kelly A.,Sharma, Amrita,Bag, Seema,Klug, Dana M.,Schneider, Katherine M.,Singh, Baljinder,Jalani, Hitesh B.,Buskes, Melissa J.,Mehta, Naimee,Tanghe, Scott,Momper, Jeremiah D.,Sciotti, Richard J.,Rodriguez, Ana,Mensa-Wilmot, Kojo,Pollastri, Michael P.,Ferrins, Lori

supporting information, p. 665 - 687 (2019/01/21)

Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (NEU-1953), which was part of a series typically associated with poor aqueous solubility. In this report, we present various medicinal chemistry strategies that were used to increase the aqueous solubility and improve the physicochemical profile without sacrificing antitrypanosomal potency. To rank trypanocidal hits, a new assay (summarized in a cytocidal effective concentration (CEC50)) was established, as part of the lead selection process. Increasing the sp3 carbon content of 1 resulted in 10e (0.19 μM EC50 against T. brucei and 990 μM aqueous solubility). Further chemical exploration of 10e yielded 22a, a trypanocidal quinolinimine (EC50: 0.013 μM; aqueous solubility: 880 μM; and CEC50: 0.18 μM). Compound 22a reduced parasitemia 109 fold in trypanosome-infected mice; it is an advanced lead for HAT drug development.

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