280576-50-3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 280576-46-7 5-methoxy-1-(4-methoxyphenyl)-2,3-dihydro-1H-2-pyrrolone 

Downstream Products

• 280576-52-5 2-[allyl(methyl)amino]-5-methoxy-1-(4-methoxyphenyl)-1H-3-pyrrolecarbaldehyde 
• 823197-93-9 2-(diallylamino)-5-methoxy-1-(4-methoxyphenyl)-1H-3-pyrrolecarbaldehyde 
• 280576-60-5 2-(allylsulfanyl)-5-methoxy-1-(4-methoxyphenyl)-1H-3-pyrrolcarbaldehydeoxime 
• 280576-57-0 2-[allyl(methyl)amino]-5-methoxy-1-(4-methoxyphenyl)-1H-3-pyrrolcarbaldehydeoxime 
• 823197-99-5 N'-[[2-(diallylamino)-5-methoxy-1-(4-methoxyphenyl)-1H-pyrrol-3-yl]methylene]-4-methylbenzenesulfohydrazide 
• 823197-96-2 N'-[[2-[allyl(methyl)amino]-5-methoxy-1-(4-methoxyphenyl)-1H-pyrrol-3-yl]methylene]-4-methylbenzenesulfohydrazide 

Relevant academic research and scientific papers

1-Aryl-5-methoxy-pyrrolones as synthons for 1,3-dipolar cycloadditions

A general method is described to convert the title compound into more complex nitrogen heterocyclic systems in a short and attractive pathway. Spiroisoxazolidine 6 was obtained from the reaction of nitrone 3 with ethyl vinyl ether. Chloroformylation of pyrrolone 2 gave 1-aryl-2-chloro-5-methoxy- pyrrol-3-carbaldehyde 4. Substitution of chlorine atom with unsaturated nucleophiles 8a,b and then modifying the aldehyde function into 1,3-dipoles 10 and 14 furnished tricyclic heterocycles 11, 12 and 15 via intramolecular 1,3-dipolar cycloaddition reaction. (C) 2000 Elsevier Science Ltd.