280582-23-2Relevant academic research and scientific papers
Novel 4-substituent-N-(1-substituent-1H-pyrazol-4-yl)-5-morpholinopyrimidin-2-amine derivatives and use thereof
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Paragraph 0139; 0140; 0147-0150, (2021/02/02)
A novel 4 -substituted - N N - (1-substituted - 111H-pyra -4 - yl) -5 - morpholinopyrimidine -2 - amine derivative compound or a pharmaceutically acceptable salt thereof. A pharmaceutical composition for preventing or treating JAK3-related diseases and a method for preventing or treating JAK3-related diseases using the same as an active ingredient are provided.
INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS
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Page 199-200, (2008/06/13)
The present invention provides compounds of formula (I): These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.
2,4-diamino pyrimidine compounds having anti-cell proliferative activity
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, (2008/06/13)
A pyrimidine derivative of formula (I): wherein: R1is an optional substituent as defined within; Rxis selected from halo, hydroxy, nitro, amino, cyano, mercapto, carboxy, sulphamoyl, formamido, ureido or carbamoyl or a group of formula (Ib): A—B—C— as defined within; Q1and Q2are independently selected from aryl, a 5- or 6-membered monocyclic moiety; and a 9- or 10-membered bicyclic heterocyclic moiety; and one or both of Q1and Q2bears on any available carbon atom one substituent of formula (Ia) as defined within; and Q1and Q2are optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
