280749-78-2Relevant academic research and scientific papers
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
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Page 48-49, (2010/02/07)
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure - Activity relationship and improvement of overall properties of arylthio cinnamides
Pei,Xin,Liu,Li,Reilly,Lubbers,Huth,Link,Von Geldern,Cox,Leitza,Gao,Marsh,DeVries,Okasinski
, p. 2913 - 2920 (2007/10/03)
The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on the binding of our p-arylthiocinnamide series to LFA-1, we have identified the cyclic amide (C-
