280752-01-4

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 101273-62-5 1-methyl-5-indolethiol 
• 280563-07-7 1-methyl-5-iodoindole 
• 16066-91-4 5-iodo-1H-indole 
• 862400-26-8 2,3-dichloro-4-(1-methyl-1H-indol-5-ylsulfanyl)-benzaldehyde 
• 280753-07-3 (1-methylindol-5-yl)[2,3-dichloro-4-(E-(carboxy)ethenyl)phenyl]sulfide 

Relevant academic research and scientific papers

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure - Activity relationship of substituents on the benzene ring of the cinnamide

We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We now show that 2,3-disubstitution on the aryl portion of the cinnamide results in enhanced activit