280773-47-9

Basic information

• Product Name: 4-ethyl-2-iodoaniline
• Synonyms: 4-ethyl-2-iodoaniline
• CAS NO: 280773-47-9
• Molecular Weight: 247.079
• Mol File: 280773-47-9.mol

Chemical Properties

• CAS DataBase Reference: 4-ethyl-2-iodoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-2-iodoaniline(280773-47-9)
• EPA Substance Registry System: 4-ethyl-2-iodoaniline(280773-47-9)

Safety Data

• Hazardous Substances Data: 280773-47-9(Hazardous Substances Data)

Upstream product

• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 1200070-39-8 N-(4-ethyl-2-iodophenyl)methanesulfonamide 
• 1421437-50-4 5-ethyl-2-phenyl-1H-benzo[d]imidazole 
• 21224-17-9 6-ethyl-3H-benzothiazole-2-thione 
• 1388136-10-4 N-(4-ethyl-2-(phenylethynyl)phenyl)-4-methylbenzenesulfonamide 
• 1242303-56-5 6-ethyl-2-phenylbenzo[d]thiazole 

Relevant articles and documents

The Multiple Facets of Iodine(III) Compounds in an Unprecedented Catalytic Auto-amination for Chiral Amine Synthesis

Iodine(III) reagents are used in catalytic one-pot reactions, first as both oxidants and substrates, then as cross-coupling partners, to afford chiral polyfunctionalized amines. The strategy relies on an initial catalytic auto C(sp3)?H amination of the iodine(III) oxidant, which delivers an amine-derived iodine(I) product that is subsequently used in palladium-catalyzed cross-couplings to afford a variety of useful building blocks with high yields and excellent stereoselectivities. This study demonstrates the concept of self-amination of the hypervalent iodine reagents, which increases the value of the aryl moiety.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

A useful and convenient synthetic protocol for iodination of organic substrates using a combination of vanadyl acetylacetonate, hydrogen peroxide, and sodium iodide

A wide variety of organic substrates can be iodinated selectively in good yields by employing a combination of vanadyl acetylacetonate, hydrogen peroxide, and sodium iodide at ice-bath temperature. Good yield, selectivity, use of cost effective reagents, and mild and environmentally benign reaction conditions are some of the major advantages of this protocol.

Pd/C-Mediated synthesis of indoles in water

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,s 5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.

AROMATIC AMIDES

This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.