280783-56-4

Basic information

• Product Name: 8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
• CAS NO: 280783-56-4
• Molecular Weight: 401.552
• Mol File: 280783-56-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(280783-56-4)
• EPA Substance Registry System: 8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one(280783-56-4)

Safety Data

• Hazardous Substances Data: 280783-56-4(Hazardous Substances Data)

Upstream product

• 309254-70-4 β-(3,4-Dihydro-1-naphthyl)propionic acid 
• 100371-82-2 2,3,3a,4,5,6-hexahydro-phenalen-1-one oxime 
• 62715-22-4 (RS)-2,3,3a,4,5,6-hexahydro-phenalen-1-one 
• 70067-71-9 (RS)-3-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid 
• 309254-78-2 (1S,3aS)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile 
• 159949-24-3 (S)-3-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid 
• 159949-23-2 (S)-2,3,3a,4,5,6-hexahydro-phenalen-1-one 
• 309254-84-0 (1S,3aR)-1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-4-phenylamino-piperidine-4-carbonitrile 
• 309254-80-6 (R)-3-(1,2,3,4-tetrahydro-naphthalen-1-yl)-propionic acid 
• 309254-81-7 (R)-2,3,3a,4,5,6-hexahydro-phenalen-1-one 

Relevant articles and documents

1,3,8-triazaspiro[4,5]decan-4-one derivatives

The present invention relates to compounds of the formula wherein R1 and R2 are each independently hydrogen, lower alkyl, lower alkoxy or halogen; R3 is phenyl, which is unsubstituted or substituted by lower alkyl, CF3, lower alkoxy or halogen; R4 is hydrogen, lower alkyl, lower alkenyl, -C(O)-lower alkyl, -C(O)-phenyl, lower alkyl-C(O)-phenyl, lower alkylene-C(O)O-lower alkyl, lower alkantriyl-di-C(O)O-lower alkyl, hydroxy-lower alkyl, lower alkyl-O-lower alkyl, lower alkyl-CH(OH)CF3, phenyl or benzyl, R5 and R6 are each independently hydrogen, phenyl, lower alkyl or di-lower alkyl or R5 and R6 together with the carbon atoms to which they are bound form a phenyl ring, or R5 and one of R1 or R2 together with the carbon atoms to which they are bound form a saturated or unsaturated 6 membered ring, A is a 4-7 membered saturated ring, their racemates and the enantiomers thereof, and the pharmaceutically acceptable acid addition salts thereof which are agonists and/or antagonists of the OFQ receptor.