28082-84-0

Usage

Bicyclic compound

Consists of a quinoxaline ring system

Substituents

Two methyl groups attached at positions 3 and 6

Common uses

Synthesis of various pharmaceuticals and bioactive molecules

Reactivity

Versatile

Pharmacological properties

Potential as an anti-cancer agent, antimicrobial, and antiviral activity

Other potential uses

Organic electronic materials, building block in the synthesis of heterocyclic compounds

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 90917-92-3 3,4-dihydro-3,6-dimethyl-1H-quinoxalin-2-one 
• 600-22-6 pyruvic acid methyl ester 
• 106-49-0 p-toluidine 
• 40781-30-4 2-chloro-N-(4-methyl-phenyl)propionamide 
• 868771-21-5 2-chloro-N-(4-methyl-2-nitro-phenyl)-propionamide 
• 868771-31-7 N-(2-amino-4-methyl-phenyl)-2-chloro-propionamide 

Relevant academic research and scientific papers

To what extent are the photophysical properties of quinoxaline- and quinoxalinone-based chromophores predictable?

A series of chromophores containing quinoxaline or quinoxalinone electron-acceptor (A) and dialkylaminostyryl electron-donor (D) units linked by π electronic bridge has been synthesized. Electronic emission and absorption spectra of the novel D-π-A, D-π-A-π-D or D-π-A-π-A-π-D systems cover a broad range from ultraviolet to near infrared. Positions and relative intensities of their absorption bands are shown to depend strongly on structural modifications of the molecules, while emission in solution strongly depends on both the structure of the solute and the solvent polarity. Quantum chemical modeling provided a reliable description of the observed absorption spectra and reproduced the positions of the emission bands. Quantum yields of emission are shown to be qualitatively predictable on the basis of empirical rules connecting the luminescence intensity with the chemical structures of both quinoxaline- and quinoxalinone-based luminopohores and the polarity of the solvents used. Theoretical assessment of the character of the main electronic transitions suggests that simultaneous presence of D and A units conjugated via π-bridges ensures the intramolecular charge-transfer effects probably underlying the observed similar solvatochromism for all the studied systems irrespective of their polarity.

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.

Synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives

Substituted 1,3-dimethyl-1H-quinoxalin-2-ones (7) have been synthesized through the procedures of acylation, nitration, reduction, intramolecular alkylation, oxidation, and N-methylation starting from 3,4-disubstituted aniline.

Novel approach to 3-methyl-1H-quinoxalin-2-ones

A novel approach to the synthesis of 3-methyl-1H-quinoxalin-2-ones has been described. These compounds were regioselectively prepared by starting from substituted phenylamines and α-chloropropionyl chloride through the efficient procedures of acylation, nitration, reduction, intramolecular alkylation, and oxidation. Copyright Taylor & Francis, Inc.