28094-15-7

Basic information

• Product Name: 6-HYDROXYDOPAMINE HYDROCHLORIDE
• Synonyms: 4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride;6-Hd HCl;Nsc233898;OxidopaMine Hydrochloride;TopaMine Hydrochloride;5-(2-aMinoethyl)benzene-1,2,4-triol hydrochloride;OxydopaMine HCL;6-OHDA
• CAS NO: 28094-15-7
• Molecular Formula: C₈H₁₁NO₃*ClH
• Molecular Weight: 205.64
• EINECS: 248-837-2
• Mol File: 28094-15-7.mol

Chemical Properties

• Melting Point: 232-233 °C (dec.)(lit.)
• Boiling Point: 406 °C at 760 mmHg
• Flash Point: 199.3 °C
• Appearance: off-white to brown/powder
• Density: g/cm³
• Vapor Pressure: 3.58E-07mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: H2O: >50 mg/mL, clear, yellow to brown
• BRN: 4274007
• CAS DataBase Reference: 6-HYDROXYDOPAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-HYDROXYDOPAMINE HYDROCHLORIDE(28094-15-7)
• EPA Substance Registry System: 6-HYDROXYDOPAMINE HYDROCHLORIDE(28094-15-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DC4650000
• F: 3-8-10-23
• Hazardous Substances Data: 28094-15-7(Hazardous Substances Data)

Usage

Uses

Used in Neuroscience Research:
6-HYDROXYDOPAMINE HYDROCHLORIDE is used as a neurotoxin for the creation of animal models of Parkinson's disease. It causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, which helps researchers study the progression and potential treatments for the disease.
Used in Cytotoxicity Studies:
6-HYDROXYDOPAMINE HYDROCHLORIDE is used as a cytotoxic agent for analyzing the cytotoxic effects on PC12 cell line, a widely used model for studying neuronal cell lines and their response to various stimuli.
Used in Neuronal Deletion Studies:
6-HYDROXYDOPAMINE HYDROCHLORIDE is used as a neurotoxin for inducing noradrenergic (NA) neuron deletion from the locus-coeruleus, a region in the brain involved in various functions such as attention, mood regulation, and stress response. This application aids in understanding the role of noradrenergic neurons in these processes and their potential involvement in various neurological disorders.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.

Fire Hazard

Flash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Biochem/physiol Actions

Neurotoxin that destroys catecholaminergic terminals.

InChI:InChI=1/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

Downstream Products

• 41596-66-1 2-hydroxy-5-(2-aminoethyl)-1,4-benzoquinone