2810-21-1 Usage
Description
(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one is a spiroisoquinoline alkaloid derived from the plant Stephania glabra. It is characterized by its specific optical rotation ([α]26D + 143°) and the presence of two methoxyl groups and an imino group. (8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one can yield a crystalline N-acetyl derivative with a melting point of 234-5°C and an optical rotation of [α]24D 80°. The N-methyl compound of this substance has been identified as identical to Pronuciferine.
Uses
1. Used in Pharmaceutical Industry:
(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one is used as a pharmaceutical compound for its potential therapeutic applications. The alkaloid's unique structure and properties make it a candidate for the development of new drugs, particularly in the treatment of various diseases and conditions.
2. Used in Chemical Research:
In the field of chemical research, this spiroisoquinoline alkaloid can be utilized for studying the structure-activity relationships of related compounds and for understanding the chemical properties and reactivity of spiroisoquinoline alkaloids in general. This knowledge can contribute to the design and synthesis of novel compounds with potential applications in various industries.
3. Used in Natural Product Chemistry:
As a naturally occurring compound found in the plant Stephania glabra, (8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one can be a valuable resource in natural product chemistry. It may be used for the isolation and characterization of bioactive compounds from natural sources, which can lead to the discovery of new drugs or other useful applications.
4. Used in Drug Synthesis:
The unique structure of this spiroisoquinoline alkaloid makes it a potential candidate for use in drug synthesis. It can be employed as a starting material or a key intermediate in the synthesis of new pharmaceutical compounds, particularly those targeting specific biological pathways or receptors.
5. Used in Analytical Chemistry:
(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one can be used as a reference compound in analytical chemistry for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or mass spectrometry (MS), for the detection and quantification of related compounds in complex samples.
References
Cava et al., Chern. Ind., 282 (1964)
Tomita et al., Tetrahedron Lett., 2825 (1965)
Baldwin et al., J. Chern. Soc., C, 154 (1967)
Circular dichroism:
Snatzke, Wollenberg., J. Chern. Soc., C, 1681 (1966)
Check Digit Verification of cas no
The CAS Registry Mumber 2810-21-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,1 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2810-21:
(6*2)+(5*8)+(4*1)+(3*0)+(2*2)+(1*1)=61
61 % 10 = 1
So 2810-21-1 is a valid CAS Registry Number.
