28117-45-5

Upstream product

• 64187-29-7 Z-L-Leu-OCH₂CN 
• 100-46-9 benzylamine 
• 2018-66-8 Z-Leu-OH 
• 1803-64-1 (3-oxobutanoyl)-L-leucine 
• 51021-87-5 N-benzyloxycarbonyl-L-leucine methyl ester 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 
• 35006-47-4 (S)-4-isobutyl-2-((E)-2-oxo-propylidene)-oxazolidin-5-one 
• 501-53-1 benzyl chloroformate 
• 61-90-5 L-leucine 
• 4091-51-4 N-Benzyloxycarbonyl-L-leucin- 

Downstream Products

• 675874-53-0 {(S)-1-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 675874-59-6 {(1S,2S)-1-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-2-methyl-butyl}-carbamic acid benzyl ester 
• 675874-57-4 (S)-2-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 675874-49-4 {(S)-1-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester 
• 675874-51-8 {(S)-1-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester 
• 675874-55-2 {(S)-1-[(S)-1-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-ethyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Amidation of unactivated ester derivatives mediated by trifluoroethanol

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

Mechanistic implications of the enantioselective addition of alkylzinc reagents to aldehydes catalyzed by nickel complexes with α-amino amide ligands

The enantioselective alkylation of aldehydes catalysed by nickel(ii)-complexes derived from α-amino amides was studied by means of density functional theory (DFT) and ONIOM (B3LYP:UFF) calculations. A mechanism was proposed in order to investigate the origin of enantioselectivity. The chirality-determining step for the alkylation was the formation of the intermediate complexes with the involvement of a 5/4/4-fused tricyclic transition state. The predominant products predicted theoretically were of (S)-configuration, in good agreement with experimental observations. The scope of the reaction was examined and high yields and enantioselectivities were observed for the enantioselective addition of Et2Zn and Me2Zn to aromatic and aliphatic aldehydes.

Circular dichroism studies on absolute configuration assignment of peptidomimetics with a terminal chiral 3-arylpropionic acid unit

The relationship between the molecular structure of peptidomimetics 1 and their chiroptical properties has been studied using circular dichroism spectroscopy. It was demonstrated that the sign of the Cotton effects occurring around 230 and 270 nm enables the direct assignment of stereochemistry at C-1 and C-3 carbon atoms. The TD-DFT calculations of the circular dichroism (CD) spectrum of one of the model compounds confirm the absolute stereochemistry assignment made experimentally. Thus, CD spectroscopy proved to be a simple, reliable and general tool for the determination of the absolute configuration of the stereogenic centers of peptidomimetics with a terminal 3-arylpropionic group.

Arecoline Tripeptide Inhibitors of Proteasome

The 26S proteasome is a multicatalytic protease complex that plays an essential role in intracellular protein degradation. We have synthesized and tested a series of arecoline peptide derivatives where the peptide portion derives from a screening of tripe

Amino acid derivatives

Compounds of the formula wherein R1 represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, aroyl, cycloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyl-alkanoyl, 6-(dibenzylcarbamoyl)-4-oxohexanoyl or an acyl group of an α-amino acid in which