28118-80-1

Basic information

• Product Name: 1-phenyl-3-(triphenyl-lambda~5~-phosphanylidene)pyrrolidine-2,5-dione
• CAS NO: 28118-80-1
• Molecular Formula: C₂₈H₂₂NO₂P
• Molecular Weight: 435.4535
• Mol File: 28118-80-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 598°C at 760 mmHg
• Flash Point: 315.5°C
• Density: 1.29g/cm³
• Vapor Pressure: 2.9E-14mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 1-phenyl-3-(triphenyl-lambda~5~-phosphanylidene)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(triphenyl-lambda~5~-phosphanylidene)pyrrolidine-2,5-dione(28118-80-1)
• EPA Substance Registry System: 1-phenyl-3-(triphenyl-lambda~5~-phosphanylidene)pyrrolidine-2,5-dione(28118-80-1)

Safety Data

• Hazardous Substances Data: 28118-80-1(Hazardous Substances Data)

Usage

Molecular structure

The compound has a complex structure that includes a pyrrolidine-2,5-dione core and a phosphanylidene group.

Phosphorus oxidation state

The term "lambda~5~-phosphanylidene" indicates that the phosphorus atom is in a formal oxidation state of +1.

Phenyl group

The compound contains a phenyl group, which consists of a six-carbon ring with a single hydrogen atom attached.

Potential applications

The compound has potential applications in organic synthesis and medicinal chemistry due to its unique structure and properties.

Building block

It may be used as a building block for the synthesis of more complex molecules.

Ligand in coordination chemistry

The compound may also be used as a ligand in coordination chemistry.

Interesting target for research

Its properties and potential uses make it an interesting target for further research and development in the field of chemistry.

Upstream product

• 941-69-5 N-phenyl-maleimide 
• 603-35-0 triphenylphosphine 
• 62-53-3 aniline 

Downstream Products

• 58684-78-9 5,6-dimethyl-2-phenyl-3',4,7,7'-tetrahydro-2H-isoindole-1,3-dione 
• 1233975-63-7 N-phenyl-1,6-methano[10]annulene-3,4-dicarboximide 

Relevant articles and documents

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

A series of 4-(phenoxymethyl)thiazole derivatives was synthesized and evaluated for their GPR119 agonistic effect. Several 4-(phenoxymethyl)thiazoles with pyrrolidine-2,5-dione moieties showed potent GPR119 agonistic activities. Among them, compound 27 and 32d showed good in vitro activity with an EC50 value of 49 nM and 18 nM, respectively with improved human and rat liver microsomal stability compare with MBX-2982. Compound 27 & 32d did not exhibit significant CYP inhibition, hERG binding, and cytotoxicity. Moreover, these compounds lowered the glucose excursion in mice in an oral glucose-tolerance test.

Iridium-catalyzed asymmetric hydrogenation of α-alkylidene succinimides

Not to be out PhOXed! The title reaction provides a new approach to chiral succinimide derivatives with excellent yields and ee values by using a low catalyst loading (0.05 mol %) and mild reaction conditions. Chiral 3-benzyl pyrrolidines and 1-hydroxypyrrolidine-2,5-diones, important structural motifs in natural products and pharmaceuticals, could be readily prepared. BARF -=tetrakis[3,5-bis(trifluoromethyl)phenyl]borate. Copyright