281190-61-2

Basic information

• Product Name: 1H-Indole-2-carbonitrile,octahydro-,(2S,3aR,7aS)-(9CI)
• Synonyms: 1H-Indole-2-carbonitrile,octahydro-,(2S,3aR,7aS)-(9CI)
• CAS NO: 281190-61-2
• Molecular Formula: C9H14N2
• Molecular Weight: 0
• Product Categories: PYRROLIDINE
• Mol File: 281190-61-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-2-carbonitrile,octahydro-,(2S,3aR,7aS)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carbonitrile,octahydro-,(2S,3aR,7aS)-(9CI)(281190-61-2)
• EPA Substance Registry System: 1H-Indole-2-carbonitrile,octahydro-,(2S,3aR,7aS)-(9CI)(281190-61-2)

Safety Data

• Hazardous Substances Data: 281190-61-2(Hazardous Substances Data)

Downstream Products

• 82717-40-6 octahydro-1H-indole-2-carboxylic acid 

Relevant articles and documents

Process for the preparation of monocyclic, bicyclic and tricyclic aminoacids

The invention relates to a process for the preparation of compounds of the formula I STR1 in which R represents hydrogen, alkyl or aralkyl, and R1 to R6 denote identical or different radicals hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aralkyl or aryl, both being monosubstituted, disubstituted or trisubstituted in the aryl moiety by alkyl, alkoxy, hydroxyl, halogen, nitro, methylenedioxy and/or cyano, or in which two of the radicals R1 to R6, together with the carbon atom(s) bearing them form a monocyclic or bicyclic ring system, and the remaining radicals are hydrogen, which process comprises converting, with an oxidizing agent in the presence of a silver salt, a pyrrolidine derivative of the formula II into a Δ1 -pyrroline derivative of the formula III, reacting the latter with hydrogen cyanide or a metal cyanide to form a nitrile of the formula IV, and subjecting the latter to solvolysis with a compound of the formula ROH.