281191-43-3

Basic information

• Product Name: (2S,1''S)-2-CYCLOPROPYL-2-(1-PHENYLETHYLAMINO)ACETIC ACID
• Synonyms: (2S,1''S)-2-CYCLOPROPYL-2-(1-PHENYLETHYLAMINO)ACETIC ACID;(2S,1'S)-Cyclopropyl-(1-phenyl-ethylaMino)-acetic acid;(S)-2-Cyclopropyl-2-((S)-1-phenylethylamino)acetic acid
• CAS NO: 281191-43-3
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.29
• Mol File: 281191-43-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2S,1''S)-2-CYCLOPROPYL-2-(1-PHENYLETHYLAMINO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,1''S)-2-CYCLOPROPYL-2-(1-PHENYLETHYLAMINO)ACETIC ACID(281191-43-3)
• EPA Substance Registry System: (2S,1''S)-2-CYCLOPROPYL-2-(1-PHENYLETHYLAMINO)ACETIC ACID(281191-43-3)

Safety Data

• Hazardous Substances Data: 281191-43-3(Hazardous Substances Data)

Usage

General Description

(2S,1''S)-2-cyclopropyl-2-(1-phenylethylamino)acetic acid is a chemical compound with a cyclopropyl group and an amino acid derivative. It is a chiral compound with two stereocenters, both of which are in the S configuration. The chemical has potential pharmaceutical applications, particularly in the field of medicinal chemistry. It may have potential as a drug candidate due to its unique structure and possible biological activity. Further research and studies on this compound may reveal its therapeutic potential and any potential side effects.

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 151-50-8 potassium cyanide 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 281191-42-2 C₁₃H₁₆N₂ 

Downstream Products

• 1188407-23-9 (S)-2-cyclopropyl-2-[(S)-1-phenylethylamino]ethanol 
• 1188407-25-1 (S)-1-cyclopropyl-2-methoxy-N-[(S)-1-phenylethyl]ethanamine 
• 1188407-45-5 (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile 
• 1350712-33-2 (S)-1-cyclopropyl-2-methyl-1-((S)-1-phenyl-ethylamino)-propan-2-ol 
• 1350712-31-0 (S)-cyclopropyl-((S)-1-phenyl-ethylamino)-acetic acid methyl ester 
• 49606-99-7 (S)-2-amino-2-cyclopropylacetic acid 

Relevant articles and documents

SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF

A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD+, and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is where n1≧1, m1≧0 and the M1 is H or a monovalent cation; the Structural Formula (II) is where n2≧0, m2≧0, the M2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.

Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity

The invention relates to the compound (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile, pharmaceutical compositions of the compound, and methods of using the compound for the treatment of psychiatric disorders and neurological diseases including depression, anxiety related disorders, irritable bowel syndrome, addiction and negative aspects of drug and alcohol withdrawal, and other conditions associated with CRF.

COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S INHIBITORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.