281191-63-7

Upstream product

• 5451-40-1 2,6 dichloropurine 
• 156126-13-5 (1aR,1bR,4aS,5S,5aS)-1a-Benzyloxymethyl-3,3-dimethyl-hexahydro-2,4-dioxa-cyclopropa[a]pentalen-5-ol 

Downstream Products

• 281191-64-8 (1'R,2'R,3'S,4'R,5'S)-4-[2-chloro-6-(cyclopentylamino)purin-9-yl]-1-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 
• 436847-22-2 (1'S,2'R,3'S,4'R,5'S)-4-(6-methylamino-2-chloro-9H-purin-9-yl)-1-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 
• 436847-21-1 (1'S,2'R,3'S,4'R,5'S)-4-(6-amino-2-chloro-9H-purin-9-yl)-1-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 
• 281191-59-1 MRS 1760 
• 352552-17-1 (1aS,1bR,4aS,5R,5aS)-5-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-3,3-dimethyl-tetrahydro-2,4-dioxa-cyclopropa[a]pentalene-1a-carboxylic acid 
• 436847-13-1 MRS 2339 
• 281191-66-0 (1'R,2'R,3'S,4'R,5'S)-4-{2-chloro-6-[(3-iodophenylmethyl)amino]purin-9-yl}-1-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexane-2,3-(O-isopropylidene) 

Relevant academic research and scientific papers

Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists

Adenosine receptor agonists have cardioprotective, cerebroprotective, and antiinflammatory properties. We report that a carbocyclic modification of the ribose moiety incorporating ring constraints is a general approach for the design of A1 and

Adenine nucleotide analogues locked in a Northern methanocarba conformation: Enhanced stability and potency as P2Y1 receptor agonists

Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a