281194-74-9

Basic information

• Product Name: 2H-Imidazol-2-one, 1-acetyl-1,3-dihydro-3,4,5-trimethyl- (9CI)
• Synonyms: 2H-Imidazol-2-one, 1-acetyl-1,3-dihydro-3,4,5-trimethyl- (9CI)
• CAS NO: 281194-74-9
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.19308
• Product Categories: ACETYLGROUP
• Mol File: 281194-74-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Imidazol-2-one, 1-acetyl-1,3-dihydro-3,4,5-trimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Imidazol-2-one, 1-acetyl-1,3-dihydro-3,4,5-trimethyl- (9CI)(281194-74-9)
• EPA Substance Registry System: 2H-Imidazol-2-one, 1-acetyl-1,3-dihydro-3,4,5-trimethyl- (9CI)(281194-74-9)

Safety Data

• Hazardous Substances Data: 281194-74-9(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 63455-73-2 1,4,5-trimethyl-1H-imidazole 3-oxide 

Relevant articles and documents

Synthesis of imidazole derivatives using 2-unsubstituted 1H-imidazole 3- oxides

The reaction of 1,4,5-trisubstituted 1H-imidazole 3-oxides 1 with Ac2O in CH2Cl2 at 0-5°leads to the corresponding 1,3-dihydro-2H-imidazol-2-ones 4 in good yields. In refluxing Ac2O, the N-oxides 1 are transformed to N- acetylated 1,3-dihydro-2H-imidazol-2-ones 5. The proposed mechanisms for these reactions are analogous to those for N-oxides of 6-membered heterocycles (Scheme2). A smooth synthesis of 1H-imidazole-2-carbonitriles 2 starting with 1 is achieved by treatment with trimethylsilanecarbonitrile (Me3SiCN) in CH2Cl2 at 0-5°(Scheme 3).