281207-63-4

Upstream product

• 25062-46-8 4-bromobenzaldehyde oxime 
• 281207-62-3 ethyl 1-[(tert-butoxy)carbonylamino]-3-methylenecyclobutanecarboxylate 

Downstream Products

• 281207-73-6 ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate 
• 281207-70-3 ethyl cis-6-aza-7-(4-bromophenyl)-5-oxa-2[(phenylamino)carbonylamino]spiro[3.4]oct-6-ene-2-carboxylate 
• 281207-66-7 ethyl cis-2-amino-6-aza-7-(4-bromophenyl)-5-oxaspiro[3.4]oct-6-ene-2-carboxylate 

Relevant academic research and scientific papers

Diastereoselective synthesis of hydantoin- and isoxazoline-substituted dispirocyclobutanoids

Synthetic strategies for constructing novel achiral cyclobutanoid isoxazolidinoimidazolidinedione heterocycles, with a generalized structure of II, have been developed via 1,3-dipolar cycloaddition and carbanilide cyclization transformations from methylenecyclobutane 13. The exo methylene cyclobutane system has made the realization of some diasteroselectivity possible, such that the H-bond (Boc-NH) directed product (i.e., 14) was obtained with 3:1 selectivity relative to the non-H-bond directed product (i.e., 15).