281209-13-0 Usage
General Description
2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline is a chemical compound that belongs to the quinoxaline class of compounds. It is composed of a quinoxaline ring with three chlorine atoms at the 2, 6, and 7 positions, and a trifluoromethyl group attached at the 3 position. 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline has been studied for its potential applications in the pharmaceutical and agricultural industries, including as a building block in the synthesis of various organic compounds. It has also been investigated for its potential biological activities, although its exact mechanisms of action and specific uses are still being explored. Additionally, it is important to handle this chemical with care, as it may pose certain health hazards and environmental risks.
Check Digit Verification of cas no
The CAS Registry Mumber 281209-13-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,1,2,0 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 281209-13:
(8*2)+(7*8)+(6*1)+(5*2)+(4*0)+(3*9)+(2*1)+(1*3)=120
120 % 10 = 0
So 281209-13-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H2Cl3F3N2/c10-3-1-5-6(2-4(3)11)17-8(12)7(16-5)9(13,14)15/h1-2H
281209-13-0Relevant articles and documents
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
Teng, Min,Johnson, Michael D.,Thomas, Christine,Kiel, Dan,Lakis, James N.,Kercher, Tim,Aytes, Shelley,Kostrowicki, Jarek,Bhumralkar, Dilip,Truesdale, Larry,May, John,Sidelman, Ulla,Kodra, Janos T.,Jorgensen, Anker Steen,Olesen, Preben Houlberg,de Jong, Johannes Cornelis,Madsen, Peter,Behrens, Carsten,Pettersson, Ingrid,Knudsen, Lotte Bjerre,Holst, Jens J.,Lau, Jesper
, p. 5472 - 5478 (2008/09/18)
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
