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2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline is a chemical compound within the quinoxaline class, characterized by a quinoxaline ring with three chlorine atoms at the 2nd, 6th, and 7th positions, and a trifluoromethyl group at the 3rd position. 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline has been the subject of research for its potential applications in both pharmaceutical and agricultural sectors, primarily as a precursor in the synthesis of various organic compounds. Its biological activities are under investigation, with the aim of understanding its mechanisms of action and identifying specific uses. Due to potential health and environmental risks, careful handling is advised.

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  • 281209-13-0 Structure
  • Basic information

    1. Product Name: 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline
    2. Synonyms: 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline
    3. CAS NO:281209-13-0
    4. Molecular Formula: C9H2Cl3F3N2
    5. Molecular Weight: 301.48
    6. EINECS: N/A
    7. Product Categories: blocks;Pyridines
    8. Mol File: 281209-13-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 312.5°Cat760mmHg
    3. Flash Point: 142.8°C
    4. Appearance: /
    5. Density: 1.68g/cm3
    6. Vapor Pressure: 0.001mmHg at 25°C
    7. Refractive Index: 1.583
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: -7.86±0.48(Predicted)
    11. CAS DataBase Reference: 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline(281209-13-0)
    13. EPA Substance Registry System: 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline(281209-13-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 281209-13-0(Hazardous Substances Data)

281209-13-0 Usage

Uses

Used in Pharmaceutical Industry:
2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline is used as a building block in the synthesis of pharmaceutical compounds for its potential to contribute to the development of new drugs. Its unique structure may offer novel properties that can be harnessed in medicinal chemistry.
Used in Agricultural Industry:
In the agricultural sector, 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline is similarly used as a building block in the synthesis of agrochemicals, potentially leading to the creation of new pesticides or other compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline is used as a key intermediate in organic synthesis for the preparation of a variety of organic compounds, leveraging its reactive sites for further chemical modifications to achieve desired molecular structures with specific properties.

Check Digit Verification of cas no

The CAS Registry Mumber 281209-13-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,1,2,0 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 281209-13:
(8*2)+(7*8)+(6*1)+(5*2)+(4*0)+(3*9)+(2*1)+(1*3)=120
120 % 10 = 0
So 281209-13-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H2Cl3F3N2/c10-3-1-5-6(2-4(3)11)17-8(12)7(16-5)9(13,14)15/h1-2H

281209-13-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline

1.2 Other means of identification

Product number -
Other names PC8276

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:281209-13-0 SDS

281209-13-0Upstream product

281209-13-0Downstream Products

281209-13-0Relevant articles and documents

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

Teng, Min,Johnson, Michael D.,Thomas, Christine,Kiel, Dan,Lakis, James N.,Kercher, Tim,Aytes, Shelley,Kostrowicki, Jarek,Bhumralkar, Dilip,Truesdale, Larry,May, John,Sidelman, Ulla,Kodra, Janos T.,Jorgensen, Anker Steen,Olesen, Preben Houlberg,de Jong, Johannes Cornelis,Madsen, Peter,Behrens, Carsten,Pettersson, Ingrid,Knudsen, Lotte Bjerre,Holst, Jens J.,Lau, Jesper

, p. 5472 - 5478 (2008/09/18)

Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.

NON-PEPTIDE GLP-1 AGONISTS

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Page/Page column 56, (2010/02/13)

Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac

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