281209-71-0 Usage
Chemical Description
Compound 2 and dipole precursor are not described in the article, so it is unclear what they are.
Uses
Used in Pharmaceutical Industry:
Compound 2 is used as a solvent for various pharmaceutical formulations, such as elixirs, syrups, and injectable solutions. Its ability to dissolve a wide range of substances, including drugs, makes it an ideal choice for this application.
Used in Cosmetics and Personal Care Industry:
Glycerol is used as a humectant in cosmetics and personal care products, such as lotions, creams, and toothpaste. It helps to retain moisture in the skin and other tissues, providing hydration and improving the overall texture and appearance.
Used in Food and Beverage Industry:
In the food and beverage industry, Compound 2 is used as a humectant to retain moisture in products, such as baked goods, confectionery, and processed foods. It also serves as a sweetening agent and a thickening agent in various recipes.
Used in Oral Drug Development for Diabetic Patients:
As a GLP-1R agonist, Compound 2 plays a key role in modulating glucagon-like peptide (GLP)-1 in diabetic patients. It helps to lower glycated hemoglobin levels, improve glycemic control, and maintain body weight, making it a potential oral drug for diabetes management.
Used in Drug Delivery Systems:
Glycerol can be utilized in the development of drug delivery systems, such as nanoparticles, to enhance the bioavailability and therapeutic outcomes of various drugs. Its ability to form hydrogen bonds with other molecules makes it a suitable candidate for improving drug delivery and targeting specific tissues or cells.
Biochem/physiol Actions
GLP-1R is a small molecule GLP-1 receptor agonist. GLP-1 receptor signaling is a predominant mechanism for regulating glucose homeostasis. Compound 2 represents a unique non-peptide tool for studying the role of GLP-1 in both in vivo and in vitro diabetes and obesity models.
Check Digit Verification of cas no
The CAS Registry Mumber 281209-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,1,2,0 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 281209-71:
(8*2)+(7*8)+(6*1)+(5*2)+(4*0)+(3*9)+(2*7)+(1*1)=130
130 % 10 = 0
So 281209-71-0 is a valid CAS Registry Number.
281209-71-0Relevant articles and documents
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
Teng, Min,Johnson, Michael D.,Thomas, Christine,Kiel, Dan,Lakis, James N.,Kercher, Tim,Aytes, Shelley,Kostrowicki, Jarek,Bhumralkar, Dilip,Truesdale, Larry,May, John,Sidelman, Ulla,Kodra, Janos T.,Jorgensen, Anker Steen,Olesen, Preben Houlberg,de Jong, Johannes Cornelis,Madsen, Peter,Behrens, Carsten,Pettersson, Ingrid,Knudsen, Lotte Bjerre,Holst, Jens J.,Lau, Jesper
, p. 5472 - 5478 (2008/09/18)
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
NON-PEPTIDE GLP-1 AGONISTS
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Page/Page column 79, (2010/02/13)
Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac
