281232-89-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Chloro-pyrimidin-4-yl)-benzoic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its role is pivotal for the production of a range of medications, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2-Chloro-pyrimidin-4-yl)-benzoic acid is employed as a fundamental component in the creation of different agrochemicals. It plays a significant part in enhancing crop protection and productivity through its incorporation into various agricultural products.
Used in Organic Chemistry Research:
CPBA is also used as a versatile building block in organic chemistry research. It is valuable for the synthesis of complex organic molecules and contributes to the advancement of chemical knowledge and innovation in the field.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 14047-29-1 4-carboxyphenylboronic acid 

Downstream Products

• 281233-85-0 4-[2-(2-Dimethylamino-ethylamino)-pyrimidin-4-yl]-benzoic acid 
• 1026028-82-9 C₂₄H₂₁N₅O₂ 

Relevant academic research and scientific papers

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model

Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited optimization of kinase selectivity, solubility, and pharmacokinetic properties were undertaken on all three series, as SAR was often transferrable. Ultimately, a 2,4-diaryl 7-azaindole was optimized to afford a tool molecule that potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line, is orally bioavailable, and crosses the blood–brain barrier. When dosed orally in rodents, compound 4 t limited ghrelin-induced food intake.

Pyrimidine-based inhibitors of CaMKIIδ

Non-ATP competitive pyrimidine-based inhibitors of CaMKIIδ were identified. Computational studies were enlisted to predict the probable mode of binding. The results of the computational studies led to the design of ATP competitive inhibitors with optimized hinge interactions. Inhibitors of this class possessed improved enzyme and cellular activity compared to early leads.

SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS

This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

A convenient synthesis of heteroaryl benzoic acids via Suzuki reaction

An one step approach to heteroaryl benzoic acids from readily accessible heteroaryl halides and carboxybenzene boronic acids is described. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous acetonitrile. The scope and limitations of the reaction are discussed.