281232-93-7

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 945756-37-6 C₁₄H₁₆ClN₃ 
• 1187660-79-2 C₄₂H₆₃N₇O₆ 
• 1187660-80-5 C₂₉H₃₉N₇O₄ 
• 1187660-78-1 C₃₂H₄₄N₆O₆S 
• 1187660-33-8 C₃₁H₄₂N₆O₄ 
• 1187660-77-0 C₁₉H₂₅ClN₄O₂ 
• 1187660-32-7 C₂₀H₂₇ClN₄O₂ 

Relevant academic research and scientific papers

4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.