28128-15-6 Usage
Uses
Used in Pharmaceutical and Agrochemical Industries:
2-Bromopurine is used as a key building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and chemical compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic and pesticidal properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-Bromopurine serves as a valuable reagent for the formation of carbon-carbon and carbon-heteroatom bonds. Its versatility in synthetic methodologies makes it an essential component in the development of novel chemical reactions and the synthesis of complex organic molecules.
Used in Drug Development:
2-Bromopurine is utilized as a precursor in the development of new drugs, particularly in the area of medicinal chemistry. Its potential use in the treatment of various diseases highlights its importance in the discovery and design of innovative therapeutic agents.
Used in Laboratory Settings:
As a brominated purine derivative, 2-Bromopurine is known for its moderate toxicity. It is used in laboratory settings with caution, ensuring proper handling and safety measures to protect researchers and the environment from potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 28128-15-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,2 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28128-15:
(7*2)+(6*8)+(5*1)+(4*2)+(3*8)+(2*1)+(1*5)=106
106 % 10 = 6
So 28128-15-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrN4/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H,7,8,9,10)
28128-15-6Relevant academic research and scientific papers
Occurrence of the SNANRORC Mechanism in the Amination of 2-Substituted Purines with Potassium Amide in Liquid Ammonia
Kos, Nico J.,Plas, Henk C. van der
, p. 2942 - 2945 (2007/10/02)
The reactions of 2-chloro-, 2-fluoro- and 2-(methylthio)purine with potassium amide in liquid ammonia lead to the formation of 2-aminopurine.When these reactions are carried out with 15N-labeled potassium amide, ring-labeled 2-aminopurine is found.This demonstrates that a ring opening occurs during the amination.Formation of an anionic ? adduct at position 6 is proven by low-temperature NMR spectroscopy, and evidence is obtained for the formation of an open-chain intermediate, although this intermediate could not be isolated in a pure state.Reaction of the open-chain intermediate with hydriodic acid gives the thus far unknown 2-iodopurine. 2-Chloro-6-phenylpurine also reacts via ring opening into 2-amino-6-phenylpurine.However, 2-chloro-6-methyl- and 2-chloro-6,8-di-tert-butylpurine are found to be unreactive.
