28128-16-7 Usage
Uses
Used in Biochemistry and Medicine Research:
2-Iodopurine is used as a nucleoside transporter inhibitor, playing a crucial role in the study of nucleoside transport mechanisms and their regulation in various biological processes.
Used in Synthesis of Nucleotides, Pharmaceuticals, and Organic Compounds:
As a biochemical intermediate, 2-Iodopurine is utilized in the synthesis of nucleotides, which are essential for DNA and RNA structure and function, as well as in the production of pharmaceuticals and other organic compounds.
Used in Drug Development:
2-Iodopurine contributes to the development of purine-based drugs, which have potential therapeutic applications in treating various diseases and conditions.
Used in Positron Emission Tomography (PET) Imaging:
2-Iodopurine is employed as a radiotracer in PET imaging studies, aiding in the visualization and diagnosis of diseases by providing detailed images of biological processes in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 28128-16-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,2 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 28128-16:
(7*2)+(6*8)+(5*1)+(4*2)+(3*8)+(2*1)+(1*6)=107
107 % 10 = 7
So 28128-16-7 is a valid CAS Registry Number.
28128-16-7Relevant academic research and scientific papers
Kos, Nico J.,Plas, Henk C. van der
, p. 2942 - 2945 (1980)
The reactions of 2-chloro-, 2-fluoro- and 2-(methylthio)purine with potassium amide in liquid ammonia lead to the formation of 2-aminopurine.When these reactions are carried out with 15N-labeled potassium amide, ring-labeled 2-aminopurine is found.This demonstrates that a ring opening occurs during the amination.Formation of an anionic ? adduct at position 6 is proven by low-temperature NMR spectroscopy, and evidence is obtained for the formation of an open-chain intermediate, although this intermediate could not be isolated in a pure state.Reaction of the open-chain intermediate with hydriodic acid gives the thus far unknown 2-iodopurine. 2-Chloro-6-phenylpurine also reacts via ring opening into 2-amino-6-phenylpurine.However, 2-chloro-6-methyl- and 2-chloro-6,8-di-tert-butylpurine are found to be unreactive.
