28141-40-4

Basic information

• Product Name: [(4-methylphenyl)amino]methanesulfonic acid
• CAS NO: 28141-40-4
• Molecular Formula: C₈H₁₀NO₃S*Na
• Molecular Weight: 201.2428
• Mol File: 28141-40-4.mol
• Article Data: 2

Chemical Properties

• Density: 1.4g/cm³
• Refractive Index: 1.612
• CAS DataBase Reference: [(4-methylphenyl)amino]methanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-methylphenyl)amino]methanesulfonic acid(28141-40-4)
• EPA Substance Registry System: [(4-methylphenyl)amino]methanesulfonic acid(28141-40-4)

Safety Data

• Hazardous Substances Data: 28141-40-4(Hazardous Substances Data)

Usage

General Description

[(4-methylphenyl)amino]methanesulfonic acid is a chemical compound with the molecular formula C8H11NO3S. It is a sulfonamide compound that contains a methylphenyl group and an amino group attached to a methanesulfonic acid moiety. [(4-methylphenyl)amino]methanesulfonic acid is often used as a reagent in organic synthesis and as a pharmaceutical intermediate. It can also act as a pH buffer agent in various chemical and biological applications. The chemical properties of [(4-methylphenyl)amino]methanesulfonic acid make it a versatile compound with potential applications in a wide range of fields.

Upstream product

• 870-72-4 sodium formaldehyde bisulfite 
• 106-49-0 p-toluidine 
• 17450-22-5 bis(4-methylphenylamino)methane 

Downstream Products

• 16728-84-0 p-tolylaminoacetonitrile 

Relevant articles and documents

A mechanistic study of the reactions of formaldehyde with aniline in the presence of sulfite

1H NMR results are reported for the reactions of hydroxymethanesulfonate, 1, with aniline and its derivatives to produce anilinomethanesulfonates, 3. The mechanism of the reaction involves dissociation of 1 to produce formaldehyde, as a steady state intermediate, which reacts with aniline to give a carbinolamine;? subsequent dehydration and reaction with sulfite produces the product. The kinetics of individual steps have been investigated. The release of sulfite from 1, measured by reaction with iodine, is shown to involve the ionised, dianionic form when pH >3. Rate constants, k2, and equilibrium constants, K2, are reported for carbinolamine formation; the values of k2, but not K2, are affected significantly by substituents in the aniline. It is deduced that the rate-limiting step in the overall formation of products 3 changes in the pH range 6-8 from carbinolamine formation to carbinolamine dehydration.