28165-52-8

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Dibromophenol is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicinal compounds.
Used in Laboratory Research:
It serves as a laboratory reagent, facilitating various chemical reactions and experiments, essential for scientific discovery and understanding of chemical processes.
Used in Instrument Calibration:
2,5-Dibromophenol is utilized as a standard in calibrating instruments and equipment, ensuring accurate measurements and reliable performance in various analytical and industrial applications.

InChI:InChI=1/C6H4Br2O/c7-4-1-2-5(8)6(9)3-4/h1-3,9H

Upstream product

• 97-52-9 2-methoxy-4-nitrophenylamine 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 95970-08-4 1,4-dibromo-2-methoxybenzene 
• 106-37-6 1.4-dibromobenzene 
• 3638-73-1 2,5-dibromoaniline 

Downstream Products

• 14401-61-7 2,4,5-tribromophenol 
• 76362-02-2 2,5-dibromo-4-nitro-phenol 
• 197961-94-7 3,6-dibromo-2-nitro-phenol 
• 98137-97-4 3,6-dibromo-2,4-dinitro-phenol 
• 100958-95-0 (2,5-dibromo-phenoxy)-acetic acid 
• 243982-82-3 2,2',4,5'-tetrabromodiphenyl ether 
• 861928-21-4 4-bromo-2-{[tert-butyl(dimethyl)silyl]oxy}benzaldehyde 
• 95970-10-8 2,4,5-tribromo-anisole 
• 815578-59-7 3,4,6-tribromo-2-nitro-phenol 
• 725714-49-8 3,4,6-tribromo-2-nitro-anisole 
• 99859-42-4 6-bromo-2,4-dinitro-3-piperidino-phenol 
• 1202019-73-5 C₃₈H₆₈Br₂O₁₅ 
• 1017261-83-4 1-benzyloxy-2,5-dibromobenzene 
• 101494-87-5 (2,5-dibromo-4-chloro-phenoxy)-acetic acid 

Relevant academic research and scientific papers

Method for hydroxylating aromatic compound

The invention provides a method for directly hydroxylating an aromatic compound. The method comprises the following steps: dissolving the aromatic compound in a solvent, adding hydrogen peroxide and anitroxide free radical compound, and reacting. The nitroxide free radical compound is used as a catalyst, hydrogen peroxide is used as an oxidizing agent, and hydroxylation of the aromatic compound is directly catalyzed and oxidized. Compared with a traditional process, the method has the advantages of high product selectivity, mild reaction conditions, reusability of the catalyst, easiness in separation of oxidation products and raw materials and the like.

Preparation method for 2,5-dibromophenol

The invention discloses an industrial preparation method for 2,5-dibromophenol. The industrial preparation method for the 2,5-dibromophenol comprises the following steps: using 2-amino-5-nitrobenzenemethyl ether as an initial raw material, and synthesizing the 2,5-dibromophenol through a four-step reaction of performing diazotization bromination, reduction, secondary diazotization bromination anddemethylation. The obtained 2,5-dibromophenol is a black solid, the purity is 97.5%, a raw material conversion rate in each step reaches 100% respectively, and a total yield of the whole process reaches 34%.

ALKYL-SUBSTITUTED 3' COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, Ar, m and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

ACYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

PYRROLIDINE-SUBSTITUTED AZAINDOLE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, A, B, D, E, G, Ar, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Tubular stacking of water-soluble toroids triggered by guest encapsulation

(Figure Presented) Coassembly of laterally grafted rod amphiphiles gives rise to the formation of water-soluble toroids with a hydrophobic interior. The toroids stack on top of each other to form a tubular container upon triggering by fullerene encapsulat

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.