281665-31-4

Upstream product

• 281665-40-5 di-t-butyl (2-bromothiophene-3,4-diyl)dicarbamate 
• 98-80-6 phenylboronic acid 
• 108180-66-1 tert-butyl {4-[(tert-butoxycarbonyl)amino]thien-3-yl}carbamate 

Downstream Products

• 849235-76-3 2-phenyl-thiophene-3,4-diamine 

Relevant academic research and scientific papers

α-Substitution of β-thienylcarbamates: Alkylation, vinylation and Pd- catalyzed coupling reactions

Reaction of the trilithio derivative of di-t-butyl thiophene-3,4- diyldicarbamate 4 with alkyl halides has led to 2-alkylthiophenedicarbamates 9 and 11 and 4-alkylthieno[3,4-d]imidazolones 12. Acid catalyzed α- alkylation of 4, using α-branched or functionalized aldehydes, has allowed the synthesis of divinylthiophenes 13 and thieno[3,2-b]pyridines 14-16, respectively. Pd-catalyzed coupling reactions involving halo- or dihalothienylcarbamates 10, 17, 18 were studied. One or two alkenyl, alkynyl, aryl groups were introduced on the thiophene nucleus. (C) 2000 Elsevier Science Ltd.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.