281669-18-9

Upstream product

• 16367-69-4 tert-butyl D-alaninate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 281669-35-0 (R)-2-[(R)-2-((R)-2-Amino-propionylamino)-2-methyl-3,3-diphenyl-propionylamino]-propionic acid tert-butyl ester 
• 281669-36-1 (R)-2-{(R)-2-[(R)-2-((R)-2-Amino-propionylamino)-propionylamino]-2-methyl-3,3-diphenyl-propionylamino}-propionic acid tert-butyl ester 
• 281669-19-0 (R)-2-[(R)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-2-methyl-3,3-diphenyl-propionylamino]-propionic acid tert-butyl ester 
• 281669-21-4 (R)-2-{(R)-2-[(R)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-propionylamino]-2-methyl-3,3-diphenyl-propionylamino}-propionic acid tert-butyl ester 
• 281669-34-9 H-D-(αMe)Dip-D-Ala-OBu^t 

Relevant academic research and scientific papers

Comparative conformational analysis of peptides based on the two Ca-tetrasubstituted, Cβ-branched, chiral α-amino acids (αMe) Dip and (αMe)Val

For the first time a number of terminally protected model peptides (to the pentamer level) of the sterically demanding α-amino acid Cα-methyl, Cα-diphenylmethylglycine, (αMe)Dip, in combination with either Ala or Gly residues, have been synthesized (by solution methods) and fully characterized. In a parallel synthesis the corresponding peptides based on the related α-amino acid Cα-methyl, Cα-isopropylglycine, (αMe)Val, have also been prepared. The results of a comparative conformational analysis, performed by using FTIR absorption, 1H NMR, and X-ray diffraction techniques, favour the conclusion that, in contrast to the potent β-turn and 310-helix promoter (αMe)Val, (αMe)Dip may induce either a folded or a fully extended conformation. These findings indicate that, despite the common Cα-methylated and Cβ-branched features, (αMe)Dip and (αMe)Val are characterized by partially divergent conformational bias.