281669-39-4

Basic information

• Product Name: (2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester
• Synonyms: (2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester
• CAS NO: 281669-39-4
• Molecular Weight: 368.476
• Mol File: 281669-39-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester(281669-39-4)
• EPA Substance Registry System: (2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester(281669-39-4)

Safety Data

• Hazardous Substances Data: 281669-39-4(Hazardous Substances Data)

Upstream product

• 16881-32-6 tert-butyl N-(benzyloxycarbonyl)glycinate 
• 6456-74-2 Glycine tert-butyl ester 
• 281669-25-8 (2-benzyloxycarbonylamino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester 

Downstream Products

• 281669-40-7 [2-(2-amino-acetylamino)-2-methyl-3,3-diphenyl-propionylamino]-acetic acid tert-butyl ester 
• 281669-26-9 [2-(2-benzyloxycarbonylamino-acetylamino)-2-methyl-3,3-diphenyl-propionylamino]-acetic acid tert-butyl ester 

Relevant articles and documents

Comparative conformational analysis of peptides based on the two Ca-tetrasubstituted, Cβ-branched, chiral α-amino acids (αMe) Dip and (αMe)Val

For the first time a number of terminally protected model peptides (to the pentamer level) of the sterically demanding α-amino acid Cα-methyl, Cα-diphenylmethylglycine, (αMe)Dip, in combination with either Ala or Gly residues, have been synthesized (by solution methods) and fully characterized. In a parallel synthesis the corresponding peptides based on the related α-amino acid Cα-methyl, Cα-isopropylglycine, (αMe)Val, have also been prepared. The results of a comparative conformational analysis, performed by using FTIR absorption, 1H NMR, and X-ray diffraction techniques, favour the conclusion that, in contrast to the potent β-turn and 310-helix promoter (αMe)Val, (αMe)Dip may induce either a folded or a fully extended conformation. These findings indicate that, despite the common Cα-methylated and Cβ-branched features, (αMe)Dip and (αMe)Val are characterized by partially divergent conformational bias.