28172-18-1Relevant articles and documents
Two step synthesis of a non-symmetric acetylcholinesterase reactivator
Musilek, Kamil,Kuca, Kamil,Dohnal, Vlastimil,Jun, Daniel,Marek, Jan,Koleckar, Vit
, p. 1755 - 1761 (2007)
The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium) -but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage
Musilek, Kamil,Pavlikova, Ruzena,Marek, Jan,Komloova, Marketa,Holas, Ondrej,Hrabinova, Martina,Pohanka, Miroslav,Dohnal, Vlastimil,Dolezal, Martin,Gunn-Moore, Frank,Kuca, Kamil
, p. 245 - 253 (2011)
Carbamate inhibitors (e.g. pyridostigmine bromide) are used as a pre-treatment for the prevention of organophosphorus poisoning. They work by blocking the native function of acetylcholinesterases (AChE) and thus protect AChE against irreversible inhibitio
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker-Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
Musilek, Kamil,Holas, Ondrej,Kuca, Kamil,Jun, Daniel,Dohnal, Vlastimil,Opletalova, Veronika,Dolezal, Martin
, p. 3172 - 3176 (2008/02/05)
Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared