28179-02-4Relevant academic research and scientific papers
VASOCONSTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES
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, (2008/06/13)
The present invention is concerned with compounds of formula STR1 the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R 1 is hydrogen or C. sub.1-6 alkyl; R 2 is hydrogen or C 1-6 alkyl; R. sup.3 is hydrogen or C 1-6 alkyl; R 4 is hydrogen, halo, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy, aryloxy or arylmethoxy; R 5 and R 6 designate R 5a and R 6a wherein R 5a and R 6a taken together form a bivalent radical; or R 5 and R 6 can designate R. sup.5b and R. sup.6b wherein R 5b is hydrogen and R 6b is a heterocycle or an optionally substituted alkenyl or alkynyl group; or R. sup.5 and R 6 designate R 5c and R 6c, wherein R. sup.5c and R 6c are hydrogen, halo, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, hydroxy, C 1-6 alkyloxy, cyano, aminoC. sub.1-6 alkyl, carboxyl, C 1-6 alkyloxycarbonyl, nitro, amino, aminocarbonyl, C 1-6 alkylcarbonylamino, or mono-di(C 1-6 alkyl)amino; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula STR2 pharmaceutical compositions, preparations and use as a medicine are also described.
