2818-70-4

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-2-METHYLBENZIMIDAZOLE is used as an intermediate in the synthesis of various pharmaceuticals for its potential antimicrobial and antifungal properties, which are instrumental in developing treatments for a range of infections.
Used in Veterinary Medicine:
In the veterinary field, 5-IODO-2-METHYLBENZIMIDAZOLE serves as an intermediate in the production of drugs, leveraging its antimicrobial and antifungal attributes to address infections in animals.
Used in Agrochemical Production:
5-IODO-2-METHYLBENZIMIDAZOLE is utilized in the manufacturing of agrochemicals, where its properties contribute to the development of products designed to protect crops from microbial and fungal threats.
Used in Dye Manufacturing:
5-IODO-2-METHYLBENZIMIDAZOLE is also employed in the production of dyes, capitalizing on its chemical structure to create a variety of colorants used in different industries.
Overall, 5-IODO-2-METHYLBENZIMIDAZOLE's versatility and broad applications underscore its importance across multiple sectors, particularly in the development and manufacturing of products that require its unique properties.

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 20691-72-9 4-iodo-2-nitroaniline 
• 75-07-0 acetaldehyde 

Relevant academic research and scientific papers

Exploring the Strength of the H-Bond in Synthetic Models for Heme Proteins: The Importance of the N?H Acidity of the Distal Base

The distal hydrogen bond (H-bond) in dioxygen-binding proteins is crucial for the discrimination of O2with respect to CO or NO. We report the preparation and characterization of a series of ZnIIporphyrins, with one of three meso-phenyl rings bearing both an alkyl-tethered proximal imidazole ligand and a heterocyclic distal H-bond donor connected by a rigid acetylene spacer. Previously, we had validated the corresponding CoIIcomplexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to CoII-bound dioxygen. Here, we systematically vary the H-bond donor ability of the distal heterocycles, as predicted based on pKavalues. The H-bond in the dioxygen adducts of the CoIIporphyrins was directly measured by Q-band Davies-ENDOR spectroscopy. It was shown that the strength of the hyperfine coupling between the dioxygen radical and the distal H-atom increases with enhanced acidity of the H-bond donor.

Indium-mediated one-pot benzimidazole synthesis from 2-nitroanilines or 1,2-dinitroarenes with orthoesters

One-pot reduction-triggered heterocyclizations from 2-nitroanilines or 1,2-dinitroarenes to benzimidazoles were investigated in this study. In the presence of indium/AcOH in ethyl acetate at reflux, reaction of 2-nitroanilines or 1,2-dinitroarenes with R-C(OMe)3 (R=Me, Ph) produced excellent yields of the corresponding benzimidazoles within 30 min to 6 h depending on the substituents of the starting materials. Indium-mediated heterocyclization of 2-nitroanilines to benzimidazole was faster and had better yields than 1,2-dinitroarenes to benzimidazole under similar reaction conditions.