282089-45-6Relevant academic research and scientific papers
Azidophosphonium salt-directed chemoselective synthesis of (E)/(Z)-cinnamyl-1H-Triazoles and regiospecific access to bromomethylcoumarins from Morita-Baylis-Hillman adducts
Karthikeyan, Soundararajan,Shobana, Radha Krishnan,Subimol, Kamarajapurathu Raju,Helen Ratna Monica,Kumar, Ayyanoth Karthik Krishna
, p. 1579 - 1587 (2020/09/16)
The direct transformation of Morita-Baylis-Hillman (MBH) adducts into molecules of interest is a crucial process wherein allylic hydroxy-protected or halogenated MBH adducts are commonly preferred. Herein, we report an azidophosphonium salt (AzPS)-catalys
N-Acylazole mediated stereoselective and regioselective synthesis of N-substituted azole acrylonitriles
Aydin, Osman,K?kten, ?ule,ünver, Hakan,?elik, ?lhami
, p. 1134 - 1148 (2019/09/10)
Regio- and stereoselective synthesis of N -substituted azole acrylonitriles has been achieved smoothly in N, N -dimethylformamide (DMF) in the presence of potassium carbonate (K 2 CO 3) as a base catalyst. N -Substituted azole acrylonitriles were obtained
An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis-Hillman reaction
Narendar Reddy, Thatikonda,Raktani, Bikshapathi,Perla, Ramesh,Ravinder, Mettu,Vaidya, Jayathirtha Rao,Babu, N. Jagadeesh
, p. 9203 - 9209 (2017/08/29)
Herein, a facile and efficient method for the preparation of allyl amides from the aldehyde of Baylis-Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition. The effects of solvents and temperature on the reaction and substituents on the phenyl ring have been examined. This method is best demonstrated by its advantages such as operational simplicity, moderate to excellent yields, short reaction time, and simple reaction procedure. Most importantly, the reaction proceeds smoothly in the absence of a catalyst and an external oxidant.
Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents
Reddy, Thatikonda Narendar,Ravinder, Mettu,Bikshapathi, Raktani,Sujitha, Pombala,Kumar, C. Ganesh,Rao, Vaidya Jayathirtha
, p. 2832 - 2844 (2017/10/06)
A series of pyran derivatives (5–27) were synthesized in good yields by utilizing Baylis–Hillman chemistry and were further investigated for their in vitro anticancer, antibacterial, and antifungal activities. Most of the tested compounds exhibited promis
Synthesis and biological evaluation of new epalrestat analogues as aldose reductase inhibitors (ARIs)
Reddy, Thatikonda Narendar,Ravinder, Mettu,Bagul, Pankaj,Ravikanti, Keerthi,Bagul, Chandrakant,Nanubolu, Jagadeesh Babu,Srinivas, Kolupula,Banerjee, Sanjay K.,Rao, Vaidya Jayathirtha
, p. 53 - 66 (2014/01/06)
Baylis-Hillman chemistry derived four series of new epalrestat analogues were synthesized. Three structural changes are introduced in these 39 new epalrestat analogues synthesized. All compounds were evaluated for their in vitro aldose reductase inhibitor
Micellar promiscuity: An expeditious approach to Morita-Baylis-Hillman reaction
Shairgojray, Bashir Ahmad,Dar, Aijaz Ahmad,Bhat, Bilal Ahmad
, p. 2391 - 2394 (2013/06/27)
An accelerated and efficient method for Morita-Baylis-Hillman (MBH) reaction in aqueous cationic micellar solution under ambient conditions has been developed. The present method holds promise for future use of cyclic and acylic MBH-adducts of general uti
A multi-component reaction in the Morita-Baylis-Hillman route
Pal, Sudhir Chandra,Bhunia, Sankar Chandra
, p. 4816 - 4822 (2013/08/23)
A facile stereoselective synthesis of trisubstituted (Z)/(E)-alkenes containing a functionalized thioether unit has been accomplished by using a new three-component tetramolecular reaction (ABCB′-type) following a Morita-Baylis-Hillman (MBH) route. Synthe
Antimitotic activity on sea urchin embryonic cells of seven antiparasitic morita-baylis-hillman adducts: A potential new class of anticancer drugs
Leite, Jocelmo C. A.,Marques-Santos, Luis F.,Claudio Jr., G. L.,Silva, Fabio P. L.,Sousa, Suervy C. O.,Vasconcellos, Mario L. A. A.
, p. 1003 - 1011,9 (2012/12/12)
In the present work we described improvements in the 1-7 antiparasitic Morita-Baylis-Hillman Adducts synthesis and their antimitotic activity on sea urchin embryonic cells. The 2-[Hydroxy(2-nitrophenyl)methyl]acrylonitrile (1) and 2-[Hydroxy(4-bromophenyl
Triphosgene mediated chlorination of Baylis-Hillman adducts
Thatikonda, Narender Reddy,Chebolu, Naga Sesha Sai Pavan Kumar,Budde, Mahendar,Vaidya, Jayathirtha Rao
body text, p. 513 - 519 (2012/07/30)
An efficient method for the preparation of allyl chlorides from Baylis-Hillman adducts has been developed using triphosgene/pyridine system. This method is best illustrated by its advantages like operational simplicity, excellent yields, short reaction ti
Microwave irradiation or low temperature improved synthesis of antiparasitic morita-baylis-hillman adducts
Claudio Jr.,Silva, Fabio P.L.,De Oliveira, Ramon G.,Subrinho, Fernanda L.,De Andrade, Natalia G.,Vasconcellos, Mario L.A.A.
scheme or table, p. 2220 - 2224 (2012/02/03)
It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 °C or conventional protocol at 0 °C to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%). It is shown that the reaction of 2-hydroxy(4-bromophenyl)methyl acrylate formation is reversible at 120 °C.
