282104-52-3Relevant academic research and scientific papers
Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria
Plech, Tomasz,Wujec, Monika,Kosikowska, Urszula,Malm, Anna,Rajtar, Barbara,Polz-Dacewicz, Malgorzata
, p. 128 - 134 (2013/03/28)
A series of novel 1,2,4-triazole-ciprofloxacin hybrids was designed, synthesised and evaluated in vitro against drug-susceptible and drug-resistant bacteria. A significant part of the compounds obtained showed antibacterial activity higher than the activity of ciprofloxacin, both towards Gram-positive and Gram-negative species. Despite relatively small number of synthesised derivatives, it was possible to observe important dependences between their structure and activity.
