2822-77-7Relevant academic research and scientific papers
Synthesis of Two Optical Isomers of the Insect Anti-juvenile Hormone Agent Fluoromevalonolactone (FMev) and Their Biological Activities
Shuto, Akira,Kuwano, Eiichi,Eto, Morifusa
, p. 915 - 920 (2007/10/02)
The optical isomers (R)-(-)- and (S)-(+)-tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one (fluoromevalonolactone, FMev) of the insect anti-juvenile hormone were synthesized by using combined enzymatic and chemical methods, and their biological activities were examined by using the silkworm Bombyx mori L.It was found that the observed anti-juvenile hormone and insecticidal activity against Bombyx mori after topical treatment with racemic FMev was due to the (R)-(-)- enantiomer of FMev, the (S)-(+)-enantiomer being inactive.
