28221-20-7

Usage

Uses

Used in Perfume and Flavoring Production:
[1R-(1alpha,2beta,5alpha)]-2-isopropenyl-5-methylcyclohexyl isovalerate is used as a key ingredient in the production of perfumes and flavorings due to its distinctive, fruity scent. Its natural and pleasant aroma makes it a valuable addition to these products.
Used in Cosmetics and Personal Care Products:
In the cosmetics and personal care industry, [1R-(1alpha,2beta,5alpha)]-2-isopropenyl-5-methylcyclohexyl isovalerate is used as a fragrance component to impart a fresh and appealing scent to products such as lotions, creams, and shampoos. Its natural origin and safety profile contribute to the growing demand for natural ingredients in personal care products.
Used in Household Products:
[1R-(1alpha,2beta,5alpha)]-2-isopropenyl-5-methylcyclohexyl isovalerate is also used as a fragrance in household products like air fresheners and detergents. Its ability to provide a long-lasting and pleasant aroma makes it a popular choice for enhancing the scent of these everyday items.
Used in Food Products:
As a natural flavoring substance, [1R-(1alpha,2beta,5alpha)]-2-isopropenyl-5-methylcyclohexyl isovalerate is used in the food industry to add a fruity note to various food products. Its safety and versatility make it suitable for a wide range of applications, from beverages to confectionery items.

Upstream product

• 503-74-2 3-methylbutyric acid 
• 2216-51-5 (-)-menthol 
• 201230-82-2 carbon monoxide 
• 115-11-7 isobutene 

Relevant academic research and scientific papers

Hydromenthoxycarbonylation of isobutylene in the presence of tetrakis(triphenylphosphine)palladium-based catalyst systems

The catalytic activity of the Pd(PPh3)4-TsOH and Pd(PPh3)4-PPh3-TsOH systems in the reaction of isobutylene hydromenthoxycarbonylation with carbon monoxide and l-menthol has been examined. It has been

Hydroxycarbonylation of isobutylene in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalyst system

The reaction of isobutylene hydroxycarbonylation with carbon monoxide and an alcohol (ethanol, 1-menthol) in the presence of the palladium acetylacetonate-triphenylphosphine-p-toluenesulfonic acid catalytic system was investigated. It was shown that the reaction proceeds regioselectively with the formation of linear products (ethyl isovalerate, 1-menthyl isovalerate). The optimum conditions for running the process were found, at which the yield of the main products is 67-79%.

Method of using a compound of menthol and L-arginine as a preparation for the topical delivery of alprostadil for the treatment of female sexual dysfunction

A manual application of a topical clitoral sensitizing compound combination consisting og L-arginine and a cooling agent comprised of Menthol and aplrostadil, wherein the combination is applicable manually to the clitoris

Topical menthol, or a related cooling compound, to induce lubrication

Vaginal Lubrication is an important component of a woman's sexual arousal. The other components are vaginal vasocongestion and the establishment of a clitoral erection. The use of menthol or any related cooling compound, topically applied to the clitoris, evokes a reflex vaginal lubrication, via the clitoral nociceptors, the spinal autonomic nerves, and inducing the reflex release of vasoactivepolypeptides adjacent to the vaginal arterioles. The vaginal lubrication can be an effective therapy for atrophic vaginitis, the most common cause of dyspareunia (pain with intercourse).

Methods to treat one or all of the defined etiologies of female sexual dysfunction

The U.S. Food and Drug Administration defines the four separate components of Female Sexual Dysfunction (FSD) to be decreased sexual desire, decreased sexual arousal, dyspareunia (pain with intercourse), and persistent difficulty in achieving or inability to achieve orgasm (anorgasmia). To establish a diagnosis of FSD, these components must be associated with personal distress, as determined by the affected woman. A topical combination of menthol/L-arginine and the specific 5-PDE inhibitor vardenafil can be used to treat any of the defined components, or a combination of two or more of the defined components of FSD, as a safe, first-line therapy for FSD.