28231-84-7

Upstream product

• 626-61-9 4-Chloropyridine 
• 106-48-9 4-chloro-phenol 
• 15854-87-2 4-iodopyridine 

Downstream Products

• 496055-22-2 [4-(4-chloro-phenoxy)-piperidin-1-yl]-oxo-acetic acid ethyl ester 
• 496055-23-3 [4-(4-chloro-phenoxy)-piperidin-1-yl]-oxo-acetic acid 
• 97839-99-1 4-(4-chlorophenoxy)-piperidine 

Relevant academic research and scientific papers

Low catalyst loadings for copper-catalyzed O-arylation of phenols with aryl and heteroaryl halides under mild conditions

A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides to afford products in good to excellent yields (up to 95%). Georg Thieme Verlag Stuttgart. New York.

Oxamides as novel NR2B selective NMDA receptor antagonists

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.