28232-17-9Relevant articles and documents
Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines
Zhou, Qizhong,Zhang, Bin,Du, Tieqi,Gu, Haining,Ye, Yuyuan,Jiang, Huajiang,Chen, Rener
, p. 327 - 333 (2013/01/15)
2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 °C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products.