28238-27-9

Upstream product

• 6342-63-8 1-(2-bromo-5-methoxyphenyl)ethanone 

Downstream Products

• 398517-30-1 1-(2-bromo-5-methoxy)phenyl-2-(2-naphthylthio)ethanone 
• 398517-36-7 3-(2-bromo-5-methoxy)phenylnaphtho[2,1-b]thiophene 
• 1215858-78-8 2-bromo-1-(2-bromo-5-methoxyphenyl)ethanone oxime 
• 1233979-78-6 5-methoxy-3-methyl-1-(p-tolylsulfonyl)indazole 

Relevant academic research and scientific papers

Copper-catalyzed cyclization of Z-oximes into 3-methyl-1,2-benzisoxazoles

A practical and effective room temperature copper-catalyzed cyclization of Z-oximes is developed. 3-Methyl-1,2-benzisoxazoles are obtained in 58-79% yields. Also, the Z-selective synthesis of o-bromo acetophenone oximes is presented for the first time.

Z-Selective synthesis of o-bromoacetophenone N-tosylhydrazones and formation of 3-methylindazoles in aqueous ethanol

A practical and effective Z-selective synthesis of o-bromoacetophenone N-tosylhydrazones is developed. Subsequent cyclization of Z-tosylhydrazones to furnish 3-methylindazoles is accomplished with the aid of copper and DMEDA in aqueous ethanol. Cyclization reactions are complete at ambient temperature in 10 min to afford the desired compounds in excellent yields.