282529-13-9Relevant articles and documents
Synthesis of a novel thyrotropin releasing hormone (TRH) analog incorporating a piperazin-2-one ring
Bhatt, Ulhas,Just, George
, p. 722 - 727 (2007/10/03)
The synthesis of a Thyrotropin Releasing Hormone (TRH) analog incorporating a piperazin-2-one ring is described. This conformationally restricted peptidomimetic attempts to retain the key recognition elements of the interaction between TRH and its receptor. The synthesis started from the protected dipeptide 2 and proceeded via the 4-nitrobenzenesulfonyl-activated intermediate 3, which was then cyclized, N-acylated, and deprotected to yield the target compound 1.