282532-75-6Relevant academic research and scientific papers
Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase
Morisaki, Naoko,Morita, Koji,Nishikawa, Asuka,Nakatsu, Noriyuki,Fukui, Yasuhisa,Hashimoto, Yuichi,Shirai, Ryuichi
, p. 2603 - 2614 (2007/10/03)
Phosphatidylinositol analogs (PI(C2)-PI(C18)) having a series of saturated fatty acid (C2-C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3- kinase). The reactivity of Pica with PI 3-kinase turned out to be comparable to that of natural PI, although PI(C18) was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction. (C) 2000 Elsevier Science Ltd.
