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Asymmetric synthesis of erythro- and threo-2-(1-hydroxyalkyl)piperidines via iodocyclocarbamation of 1-acyl-2-alkenyl-1,2,3,6-tetrahydropyridines
Comins, Daniel L.,Williams, Alfred L.
, p. 2839 - 2842 (2007/10/03)
An iodocyclocarbamation procedure has been developed for the stereoselective preparation of erythro- and threo-2-(1- hydroxyalkyl)piperidines. This methodology was utilized in the asymmetric synthesis of two piperidine alkaloids, (+)-α-conhydrine and (+)-β- conhydrine. (C) 2000 Elsevier Science Ltd.
