28255-09-6

Basic information

• Product Name: (7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione
• Synonyms: (7aS)-2,3,7,7a-Tetrahydro-4,7aβ-dimethyl-1H-indene-1,5(6H)-dione;(7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione;(7aS)-4,7aβ-Dimethyl-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione;(S)-4,7aβ-Dimethyl-2,3,5,6,7,7a-hexahydro-1H-indene-1,5-dione;2,3,7,7a-Tetrahydro-4,7aβ-dimethyl-1H-indene-1,5(6H)-dione;4,7aβ-Dimethyl-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione
• CAS NO: 28255-09-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 28255-09-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 310 ºC
• Flash Point: 116 ºC
• Appearance: /
• Density: 1.11
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: (7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione(28255-09-6)
• EPA Substance Registry System: (7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione(28255-09-6)

Safety Data

• Hazardous Substances Data: 28255-09-6(Hazardous Substances Data)

Usage

General Description

(7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione is a chemical compound with a molecular formula C11H14O2. It belongs to the class of organic compounds known as benzodioxans, which are compounds containing a benzene ring fused to either isomers of dioxan. (7aS)-4,7a-Dimethyl-5,6,7,7a-tetrahydroindan-1,5-dione is a yellow solid with a molecular weight of 178.23 g/mol. It is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The compound may also have potential applications in organic chemistry research and development due to its unique structure and properties. However, its specific uses and potential hazards have not been widely documented.

InChI:InChI=1/C11H14O2/c1-7-8-3-4-10(13)11(8,2)6-5-9(7)12/h3-6H2,1-2H3

Upstream product

• 765-69-5 2-Methylcyclopentane-1,3-dione 
• 1629-58-9 4-penten-3-one 
• 33279-05-9 N,N-diethyl-1-amino-3-pentanone 
• 34927-37-2 2-(3-oxopentyl)-2-methylcyclopentane-1,3-diones 
• 166517-15-3 2-methyl-2-(3-pentynyl)-1,3-cyclopentanedione 
• 71-43-2 benzene 
• 32830-97-0 1-chloro-3-pentanone 

Downstream Products

• 73127-66-9 7,7a-dihydro-4,7a-dimethyl-1-(p-tolylsulphonyloxy)indan-5(6H)-one 

Relevant articles and documents

Thionyl-chloride-pyridine-mediated rearrangement of tertiary alcohols

Tertiary alcohols 5 and 8 undergo rearrangement on treatment with thionyl chloride and pyridine, yielding octahydronaphthalenes 6 and 9, respectively.Alcohol 12 under similar treatment affords a mixture of tetrahydronaphthalene 14 and diene 15, whereas alcohol 22 suffers no rearrangement but produces olefin 23.

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Additive and Medium Effects on Lewis Acid-Promoted Cationic ?-Cyclizations of Alkenyl- and Alkynylcyclopentane-1,3-diones

The effects of nucleophilic additives and Bronsted acids, and solvents on BF3*Et2O-promoted cationic ?-cyclizations of alkynyl- and alkenylcyclopentane-1,3-diones are reported.The rates and selectivities of alkynyl dione cyclizations were significantly ef