2826-95-1

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-1H-indole-3-ethylamine monohydrochloride is used as a research chemical for the development of potential treatments for depression and anxiety disorders. Its action as a serotonin-norepinephrine-dopamine releasing agent makes it a candidate for further investigation into its therapeutic effects and safety profile.
Used in Controlled Substances Regulation:
In countries where it is classified as a controlled substance, 2-methyl-1H-indole-3-ethylamine monohydrochloride is used for regulatory purposes to prevent its abuse and recreational use. This classification ensures that its use is limited to medical and research applications under the supervision of qualified professionals.

InChI:InChI=1/C11H14N2.ClH/c1-8(6-12)10-7-13-11-5-3-2-4-9(10)11;/h2-5,7-8,13H,6,12H2,1H3;1H

Upstream product

• 663938-17-8 2-[2-(2-methyl-1H-indol-3-yl)ethyl]isoindoline-1,3-dione 
• 38693-08-2 2-chloro-1-(2-methyl-1H-indol-3-yl)ethan-1-one 
• 95-20-5 2-methyl-1H-indole 
• 765-43-5 Cyclopropyl methyl ketone 
• 59-88-1 phenylhydrazine hydrochloride 

Relevant academic research and scientific papers

Synthesis and cytotoxic properties of tryptamine derivatives

Abstract The cyclopropyliminium and subsequent Grandberg rearrangements of cyclopropylketone hydrozones lead to the formation of tryptamines, which were additionally substituted at either the aromatic ring atoms or the amino group. The products were tested for their cytotoxic properties against HepG2, Jurkat and HEK293 cell lines using MTT assay. The highest activity as well as the highest selectivity was found amongst the compounds derived with one benzyl substituent at the amino group. The flow cytometry technique revealed cell-type specificity in terms of the mechanism of viability inhibition. Thus, the compounds were found to induce mainly apoptosis in HEK293 and HepG2 cells, while Jurkat cells displayed late apoptotic and necrotic responses. The apoptosis pathway is most likely to include mitochondrial damage.

Synthesis method of panobinostat

The invention discloses a synthesis method of panobinostat. The synthesis method comprises a step of synthesizing 2-methyl tryptamine or hydrochloride thereof, namely taking 2-methylindole as a raw material, conducting reaction with chloroacetyl chloride or bromoacetyl bromide, and conducting reaction with potassium phthalimide to obtain the 2-methyl tryptamine. According to the technical scheme adopted by the invention, influence of toxic raw materials on the safety of a panobinostat product is avoided; meanwhile, the invention provides the synthesis method applicable to industrial production.