28266-96-8

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 129, 1988 DOI: 10.1002/jhet.5570250119

Upstream product

• 109-12-6 2-aminopyrimidine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 58609-93-1 4-{imidazo[1,2-a]pyrimidin-2-yl}aniline 
• 93745-55-2 2-(4-Nitro-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine 
• 60472-21-1 [4-(4-nitrophenyl)-1H-imidazol-2-yl]amine 
• 60472-21-1 5-(4-nitrophenyl)-1H-imidazol-2-amine 
• 103779-36-8 acetic acid-(4-imidazo[1,2-a]pyrimidin-2-yl-anilide) 

Relevant academic research and scientific papers

Studies in the imidazole series. 100. Synthesis of derivatives of imidazo[1,2-a]pyrimidine from 2-aminopyrimidines, methyl aryl ketones, and halogens

We have synthesized imidazo[1,2-a]pyrimidine derivatives by reaction of 2-aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo- and 3,6-dibromo-substituted 2-arylimidazo[1,2-a]pyrimidines.

A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2- arylimidazo[1,2-a]pyrimidines

α-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimidazo[1,2-a]pyrimidine 6 which up

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.