282720-27-8

Basic information

• Product Name: 2-(4-bromo-phenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide
• Synonyms: 2-(4-bromo-phenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide
• CAS NO: 282720-27-8
• Molecular Weight: 418.287
• Mol File: 282720-27-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-bromo-phenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromo-phenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide(282720-27-8)
• EPA Substance Registry System: 2-(4-bromo-phenyl)-2-hydroxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide(282720-27-8)

Safety Data

• Hazardous Substances Data: 282720-27-8(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 374728-19-5 N-[2-(3-methoxy-4-(prop-2-ynyloxy)phenyl)ethyl]formamide 

Relevant articles and documents

First examples of a highly stereoselective passerini reaction: A new access to enantiopure mandelamides

Achiral benzaldehydes and isocyanides could be transformed enantioselectively in a Passerini three-component reaction to chiral mandelamides by using a galacturonic acid derivative as chiral inducer.

Multicomponent reactions in fungicide research: The discovery of mandipropamid

Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew).