282723-20-0

Basic information

• Product Name: 2-Piperidino-3-chloropyridine
• Synonyms: 2-Piperidino-3-chloropyridine
• CAS NO: 282723-20-0
• Molecular Formula: C₁₀H₁₃ClN₂
• Molecular Weight: 197
• Mol File: 282723-20-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 300.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• PKA: 6.38±0.29(Predicted)
• CAS DataBase Reference: 2-Piperidino-3-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidino-3-chloropyridine(282723-20-0)
• EPA Substance Registry System: 2-Piperidino-3-chloropyridine(282723-20-0)

Safety Data

• Hazardous Substances Data: 282723-20-0(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 2402-77-9 2,3-dichloro-pyridine 
• 54231-32-2 3-chloro-2-nitropyridine 

Downstream Products

• 1294517-66-0 3-phenyl-2-(piperidin-1-yl)pyridine 
• 4556-57-4 2,4-Dipiperidino-pyridin 

Relevant articles and documents

Regioselective Amination or Alkoxylation of Halogenated Amino-, Thio- or Alkoxypyridines via Pyridyne Intermediates

The treatment of 3-halopyridines (Cl, Br) bearing an R-substituent in position 2 (R = OEt, NEt2, N-piperidyl, or SEt) or in position 5 (R = OMe, OEt, SEt, NMe2, NEt2, or aryl) with KHMDS and an amine at 25 C for 12 hours in THF provided regioselectively 3

Nucleophilic substitution reaction of amines with 3-bromo-4-nitropyridine (and 2-nitropyridine): A new nitro-group migration

On the reaction 3-bromo-4-nitropyridine with amine, three in stead of two expected products are separated. 2D NMR spectral data indicate the major product was an unexpected nitro-group migration product. To explore the rearrangement mechanism, a systematic study with various solvents and bases was undertaken. Results obtained indicate that nitro-group migration occurs in polar aprotic solvents; while expected nucleophilic substitution took place under all tested conditions.