2829-40-5Relevant academic research and scientific papers
A General Acid-Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes
Kaiser, Daniel,Tona, Veronica,Gon?alves, Carlos R.,Shaaban, Saad,Oppedisano, Alberto,Maulide, Nuno
supporting information, p. 14639 - 14643 (2019/09/17)
In comparison to the extensively studied metal-catalyzed hydroamination reaction, hydroaminomethylation has received significantly less attention despite its considerable potential to streamline amine synthesis. State-of-the-art protocols for hydroaminomethylation of alkenes rely largely on transition-metal catalysis, enabling this transformation only under highly designed and controlled conditions. Here we report a broadly applicable, acid-mediated approach to the hydroaminomethylation of unactivated alkenes and alkynes. This methodology employs cheap, readily available, and bench-stable reactants and affords the desired amines with excellent functional group tolerance and impeccable regioselectivity. The broad scope of this transformation, as well as mechanistic investigations and in situ domino functionalization reactions are reported.
PRODUCTION OF AMINES VIA A HYDROAMINOALKYLATION REACTION
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Page/Page column 62, (2019/12/04)
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C triple bond with a reactive component which is obtainable by combining an aminal or a hemiaminal ether with an acidic medium comprising trifluoroacetic acid, wherein the aminal contains two amino groups independently selected from a secondary and a tertiary amino group that are linked by a methylene group wherein one hydrogen atom may be replaced by a further substituent, and at least one of the amino groups carries a hydrogen atom at a carbon atom bound in α-position to its nitrogen atom, and the hemiaminal ether contains a secondary or a tertiary amino group which carries a hydrogen atom at a carbon atom bound in α-position to its nitrogen atom, and the secondary or tertiary amino group is linked to an alkoxy group by a methylene group wherein one hydrogen atom may be replaced by a further substituent.
Insect Juvenile Hormone Analogues: Part XI - Synthesis of Some Heteroaromatic Undecenyl and Geranyl Amides and Their Homologues
Vig, O. P.,Trehan, I. R.,Kad, G. L.,Bedi, Asha Lata,Ghose, J.
, p. 1052 - 1055 (2007/10/02)
Synthesis of some heteroaromatic long chain amides and the corresponding amines starting from undecenoic acid, 4,8-dimethyl-3(E),7-nonadienoic acid (III) and 5,9-dimethyl-4(E),8-decadienoic acid (V) and a few heteroaromatic amines are described.The compounds have been tested on common Indian red cotton bug for their JH activity.
