283147-95-5Relevant academic research and scientific papers
Multicomponent synthesis and anti-proliferative screening of biaryl triazole-containing cyclophanes
Hernández-Vázquez, Eduardo,Amador-Sánchez, Yoarhy A.,Cruz-Mendoza, Marco A.,Ramírez-Apán, María T.,Miranda, Luis D.
, (2021)
We report a practical two-step approach involving a Ugi 4-CR/ azide-alkyne cycloaddition for the synthesis of biaryl-containing cyclophanes. The series represents an extension of our previously reported macrocycles as an effort to enhance the anti-proliferative activity of this scaffold. In this variant, we incorporate a biphenyl moiety in the framework, thus enhancing the macrocycle size, lipophilicity, and structural diversity. Macrocycles were tested against different cell lines, being more cytotoxic against prostate (PC-3 and DU-145) and breast (MCF-7) tumor cells. Gratifyingly, the most active compound showed a significative enhancement of PC-3 growth inhibition with respect to our previous series, reaffirming the potential anti-proliferative activity of this kind of cyclophanes.
COMPOUNDS AND METHODS FOR PROMOTING PLANT GROWTH
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Page/Page column 61, (2021/04/30)
Disclosed herein are compounds and methods for promoting plant growth. Formulations containing one or more disclosed compounds or salts thereof, and one or more excipients are disclosed. The formulation adjuvant can be a solid carrier, a liquid carrier, or a surface-active agent. Methods for promoting plant growth typically includes applying one or more formulations to a plant, a plant part, or a growing site of plant. The plant can be a cereal, grain, or vegetable plant. The plant part can be seed or seedling of a plant. The growing site of plant can be soil before, during, or after the plant is planted or a growing medium. In some embodiments, the one or more compounds or salts thereof in the one or more formulations are in an effective amount to decrease biosynthesis and release of strigolactone plant hormones from the plant.
BIFEPRUNOX DERIVATIVES
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Page/Page column 6-7, (2009/08/16)
The present invention relates to bifeprunox derivatives of the formula (I) wherein R1 is one substituent selected from 3-OH, 4-OH, 3-OSO3H and 4-OSO3H; R2 is H; or an N-oxide or a pharmaceutically acceptable salt, a solvate or hydrate thereof, which are p
An oxidatively-activated safety catch linker for solid phase synthesis
Davies, Stephen G.,Mortimer, Duncan A. B.,Mulvaney, Andrew W.,Russell, Angela J.,Skarphedinsson, Hjalmar,Smith, Andrew D.,Vickers, Richard J.
supporting information; experimental part, p. 1625 - 1634 (2008/10/09)
A N-benzyl-4-amino-2,2-dimethylbutanoic acid-based system has been developed as a new oxidatively activated safety catch linker for reaction monitoring and optimisation on solid support. The CAN promoted oxidative debenzylation of the tertiary N-benzylamine moiety, followed by concomitant cyclisation and release of alcohols and amines has been demonstrated both in solution phase model studies and on the solid phase. The linker system has been applied to the solid phase synthesis of a collection of phenol derivatives, and to the demonstration of the attachment and release of a chiral auxiliary from a solid support. The Royal Society of Chemistry 2008.
Ionic Liquid Acceleration of Solid-Phase Suzuki-Miyaura Cross-Coupling Reactions
Revell, Jefferson D.,Ganesan
, p. 3071 - 3073 (2007/10/03)
(Equation Presented) Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupli
