283147-95-5Relevant articles and documents
Multicomponent synthesis and anti-proliferative screening of biaryl triazole-containing cyclophanes
Hernández-Vázquez, Eduardo,Amador-Sánchez, Yoarhy A.,Cruz-Mendoza, Marco A.,Ramírez-Apán, María T.,Miranda, Luis D.
, (2021)
We report a practical two-step approach involving a Ugi 4-CR/ azide-alkyne cycloaddition for the synthesis of biaryl-containing cyclophanes. The series represents an extension of our previously reported macrocycles as an effort to enhance the anti-proliferative activity of this scaffold. In this variant, we incorporate a biphenyl moiety in the framework, thus enhancing the macrocycle size, lipophilicity, and structural diversity. Macrocycles were tested against different cell lines, being more cytotoxic against prostate (PC-3 and DU-145) and breast (MCF-7) tumor cells. Gratifyingly, the most active compound showed a significative enhancement of PC-3 growth inhibition with respect to our previous series, reaffirming the potential anti-proliferative activity of this kind of cyclophanes.
BIFEPRUNOX DERIVATIVES
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Page/Page column 6-7, (2009/08/16)
The present invention relates to bifeprunox derivatives of the formula (I) wherein R1 is one substituent selected from 3-OH, 4-OH, 3-OSO3H and 4-OSO3H; R2 is H; or an N-oxide or a pharmaceutically acceptable salt, a solvate or hydrate thereof, which are p
Ionic Liquid Acceleration of Solid-Phase Suzuki-Miyaura Cross-Coupling Reactions
Revell, Jefferson D.,Ganesan
, p. 3071 - 3073 (2007/10/03)
(Equation Presented) Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupli