28317-49-9

Basic information

• Product Name: ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE
• Synonyms: ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE;Ethyl 2-chloro-2-[2-(2-chlorophenyl)hydrazono]-;2-Chloro-2-(2-chloro-phenyl-hydrazono)-acetic acid ethyl ester;Acetic acid, 2-chloro-2-[2-(2-chlorophenyl)hydrazinylidene]-, ethyl ester;ethyl (2Z)-2-chloro-2-[2-(2-chlorophenyl)hydrazin-1-ylidene]acetate
• CAS NO: 28317-49-9
• Molecular Formula: C₁₀H₁₀Cl₂N₂O₂
• Molecular Weight: 261.1
• Mol File: 28317-49-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 332.8°C at 760 mmHg
• Flash Point: 155.1°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 0.000143mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE(28317-49-9)
• EPA Substance Registry System: ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE(28317-49-9)

Safety Data

• Hazardous Substances Data: 28317-49-9(Hazardous Substances Data)

Usage

General Description

ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE is a chemical compound with the molecular formula C10H10Cl2N2O2. It is a derivative of hydrazine and is used in various industrial applications. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry reactions. ETHYL 2-CHLORO-2-[2-(2-CHLOROPHENYL)HYDRAZONO]-ACETATE is a pale yellow solid with a molecular weight of 260.106 g/mol. It is important to handle this compound with proper safety measures and precautions due to its potential hazards.

InChI:InChI=1/C10H10Cl2N2O2/c1-2-16-10(15)9(12)14-13-8-6-4-3-5-7(8)11/h3-6,13H,2H2,1H3/b14-9+

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 95-51-2 o-chloroaniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 1228805-13-7 ethyl 1-(2-chlorophenyl)-4-(2-methoxyacetyl)-1H-pyrazole-3-carboxylate 
• 1284281-45-3 1-(2-chlorophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-N,4-dimethyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-44-2 1-(2-chlorophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 891866-07-2 1-(2-chlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing 1,2,4-triazolone moiety as c-Met kinase inhibitors

A series of novel 4-phenoxyquinoline derivatives containing 1,2,4-triazolone moiety were synthesized and evaluated for their in?vitro cytotoxic activity against four cancer cell lines (HT-29, H460, A549 and MKN-45). Most of the compounds exhibited moderate-to-significant cytotoxicity. Compounds 33, 37, 39, 44, 46, 47, 53, 55, 61, 64 and 66 were further examined for their inhibitory activity against c-Met kinase. The most promising compound 47 (with c-Met IC50value of 1.57?nM) showed remarkable cytotoxicity against HT-29, H460, A549 and MKN-45?cell lines with IC50values of 0.08?μM, 0.14?μM, 0.11?μM and 0.031?μM, respectively, and thus it was 1.1- to 2.3- fold more potent than foretinib. Their preliminary structure-activity relationships (SARs) studies indicate that electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activity.

SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.